Debra Taylor reported that all the horses that their study followed returned to their pre-laminitis level of comfort, but as these horses were still alive, histology was not looked at:
Taylor D, Sperandeo A, Schumacher J, Passler T, Wooldridge A, Bell R, Cooner A, Guidry L, Matz-Creel H, Ramey I, Ramey P
Clinical Outcome of 14 Obese, Laminitic Horses Managed with the Same Rehabilitation Protocol
Journal of Equine Veterinary Science Volume 34, Issue 4, Pages 556–564, April 2014
The Laminitis Laboratory at New Bolton Centre suggest that secondary epidermal lamellae do not return to normal:
On 28 August 2017, the Laminitis Laboratory at New Bolton Center Facebook page posted:
"SELs increase the surface area of attachment between the distal phalanx and hoof capsule, but are also affected by laminitis and generally fail to regenerate normal architecture once altered by laminitis or trauma/wear-and-tear."