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The Laminitis Site

How much does pain affect insulin levels?

1/18/2015

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Significantly, according to an example given by Andy Durham in his 2008 paper The effect of metformin ... (see below), in which one horse had a fasting resting insulin at the start of the research (presumably without clinical laminitis) of 32.8 miu/l, and a fasting resting insulin after 220 days of Metformin treatment and a recurrence of clinical laminitis of 377.5 miu/l.

Factors that may affect insulin levels include:
pain, illness, PPID, excitement, stress, recent exercise, recent eating/length of fasting, obesity, genetics, fitness, time of day, time of year, reproductive status, age and environmental temperature.

Equine Vet J. 2008 Jul;40(5):493-500
The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance.
Durham AE, Rendle DI, Newton JE.

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