Often seen in “easy keeper” breeds including native ponies, Arabians, Morgans and Iberians, a horse with EMS will usually have:
1. General obesity or regional adiposity (a cresty neck, filled supraorbital hollows, fat behind the shoulders and around the tailhead, swelling around the sheath/mammory glands);
3. A predisposition to or history of laminitis - signs of chronic laminitis such as hoof rings wider at the heels, a less-than-tight white line and a change of angle in the hoof wall may be seen in the feet, and x-rays may show rotation and remodelling of the pedal bone.
Obesity develops when horses have too much food and too little exercise. As the horse becomes obese and fat cells become full, the insulin signaling pathway is disrupted, causing insulin resistance. Fat cells release pro-inflammatory chemicals that cause systemic inflammation, and hormones including leptin, a “stop eating” hormone released when the horse has excess energy stored. High levels of leptin cause the target cells to become less receptive, or resistant, to the message to stop eating, so the horse continues to eat and put on weight. Obesity may also affect liver function resulting in reduced insulin clearance and consequent hyperinsulinaemia.
Research has suggested that weight gain has a greater impact on insulin sensitivity in certain breeds, with Arabians becoming insulin resistant when fed excess energy, but Thoroughbreds showing no decrease in insulin sensitivity with weight gain.
1. Cresty neck score from 0 to 5, with scores of 3 or greater often being seen in horses with EMS. A cresty neck score of 3 is described as “Crest enlarged and thickened, so fat is deposited more heavily in middle of the neck than towards poll and withers, giving a mounded appearance. Crest fills cupped hand and begins losing side-to-side flexibility.”
2. Neck circumference.
4. Body condition scoring – 8 or 9 on the 9 point Henneke scale is considered obese, 6 and 7 overweight. A 0 to 6 scale is also used, with scores of 4 and 5 being considered overweight and obese - see Body Condition Scoring Video.
Owners of horses and ponies in Great Britain can register for the Care About Laminitis study and monitor their horse's weight online.
Some breeds appear to be more predisposed to EMS than others and there is likely to be a genetic tendency, but developing EMS may depend on certain environmental factors being present, or multiple genes being involved. For example, scurry ponies in active competition tend to have low insulin concentrations, but insulin levels rise when they are not in work, suggesting that exercise helps to prevent them developing EMS.
Breeds adapted to survival when feed is scarce, e.g. cold winters, summer droughts, may be particularly likely to become obese and develop insulin resistance when they have plentiful food all year round.
Native ponies naturally gain weight during the summer when food is abundant and lose weight during the winter, and without these seasonal changes in body condition and insulin sensitivity, horses may become increasingly obese and insulin resistant.
In 2007 it was first discovered that giving healthy horses high levels of insulin caused them to develop laminitis (Asplin et al.). It is hyperinsulinaemia, i.e. above normal levels of insulin, not insulin resistance, that causes endocrinopathic laminitis, but they are often linked, hence the term “insulin dysregulation” is now used to cover both hyperinsulinaemia and insulin resistance.
When a healthy horse eats sugar or starch, blood glucose levels rise and the pancreas releases insulin, which enables glucose to enter insulin sensitive cells, such as muscle.
This is illustrated in research by Katie Borer et al. published in 2012. Ponies with no history of laminitis (normal) and ponies with a history of laminitis (laminitic) were fed ad lib soaked Timothy hay and a daily feed of 14% sugar/starch chaff, to which 1 g/kg bodyweight of glucose, fructose and inulin, a type of fructan, were added. The previously laminitic (therefore assumed to have EMS) ponies had a much greater insulin response to glucose than the normal ponies, but their blood glucose levels showed less difference. Note that chaff plus fructan had no greater effect on insulin or glucose than chaff alone.
1. Resting insulin - a single blood sample is tested, either after the horse has fasted for at least six hours or after eating hay. “Testing horses in the fed state allows for better assessment of insulin dysregulation” (Frank and Tadros 2013), but results may be harder to interpret if sugar/starch levels of the hay are not known. Results above 20 mIU/ml are often considered diagnostic of hyperinsulinaemia, but the reference range is specific to the testing laboratory. When the horse is fasted, this test has a false negative rate of around 70%, therefore a normal result does not rule out EMS, and a dynamic test (Oral Sugar Test) should follow.
2. Oral sugar test (OST) – the horse is fasted for at least 6 hours then fed 0.15 ml/kg bodyweight Karo Light corn syrup and blood sampled at 60 and 90 minutes and tested for insulin and glucose. Insulin <45 mIU/ml is considered normal and >60 mIU/ml is considered diagnostic of insulin dysregulation. This test measures the horse’s response to sugar in the diet at the level of the digestive system, pancreas and insulin sensitive tissue.
Current tests are not reliable and horses strongly suspected of having insulin dysregulation often test negative, so diagnosis of EMS should be based on history and clinical signs as well as blood test results. Pain and stress, as well as feed, may increase insulin and glucose levels.
Diet, weight loss if necessary and exercise are key to preventing and treating EMS.
The total combined sugar and starch in the diet should be no more than 10% to keep insulin levels low, and if weight loss is required, energy fed will need to be less than energy expended. The severity of the horse’s hyperinsulinaemia will dictate how strict the sugar/starch restriction needs to be.
Some experts consider non-structural carbohydrates (NSC) to be important – NSC is sugars or ethanol soluble carbohydrates (ESC), fructans and starch, with ESC plus fructans forming water soluble carbohydrates (WSC). Others consider only ESC and starch to be important, as these directly affect insulin, but not fructans.
Low sugar/starch, high fibre forage e.g. grass hay should form the basis of the diet, ideally analysed for ESC and starch content (Equi-Analytical in the USA analyse ESC, WSC and starch), with protein, minerals, vitamins and essential fatty acids supplemented to meet minimum requirements.
A typical diet might consist of grass hay plus the recommended amount of a low calorie balancer or mineral supplement, mixed with a low sugar/starch chaff or unmolassed sugar beet, plus salt and linseed (flaxseed).
Low energy feeds should be selected to maximise intake without oversupplying calories. Looking at the analysis of feeds rather than the description is important, e.g. some "high fibre" cubes contain almost 20% combined sugar and starch and would not be suitable for most EMS horses, and feeds claiming to be approved or suitable for laminitics can contain over 14% combined sugar and starch.
Horses with insulin dysregulation that need to gain weight can be fed increased amounts of hay and/or higher energy low sugar/starch feeds such as umolassed sugar beet (beet pulp).
Weight loss is induced by restricting calories eaten and by increasing exercise if the feet are stable. A common suggestion is to feed a horse 1.5% of its ideal, or current, bodyweight (with the diet based on hay with added minerals as described above). If weight loss isn’t seen, this amount may need to be reduced, or ideally a lower energy forage sourced. Feed intake should not go below 1.2% of the horse’s bodyweight without veterinary supervision. Severe calorie restriction can worsen insulin resistance, risk hyperlipaemia and cause stereotypical behaviour.
Access to unrestricted grass commonly triggers laminitis in EMS horses, as sugars increase insulin levels and increased energy intake promotes weight gain. Access to grass should be restricted until insulin sensitivity has returned to normal, with horses turned out in a dry lot or dirt paddock if the feet are stable to encourage exercise. Many horses that have had EMS can return to pasture once weight has been lost and insulin sensitivity has returned to normal, but may need to have access to grass restricted during high risk times, such as during rapid spring growth or when grass is stressed and cannot grow due to cold weather or drought.
Factors that affect sugars in the grass include:
Sunlight - photosynthesis and sugar production increase with sunlight intensity, so sugar levels will be higher on sunny days and lower on cloudy, overcast and rainy days. Grass growing in direct sunlight will have more sugar than grass growing in the shade.
Time of day – sugar levels peak around late afternoon on a sunny day, then decrease with respiration once the sun sets, so sugars are likely to be lowest in the early morning.
Temperature – night temperatures below 5’C cause sugars to accumulate in the grass, and laminitic horses should avoid grazing during periods of sunny days and cold nights, until warmer nights or overcast weather returns.
Stress – grass needs water and nutrients to grow, and drought conditions or poor soil fertility can lead to increased sugar levels.
Grass species – improved species designed for cattle such as rye grass may have higher energy/sugar levels.
See www.safergrass.org for more information about sugar levels and grass.
Strategies for limiting grazing include short turnout periods (less than 1 hour) or grazing in hand, turnout in a small area, use of a grazing muzzle and putting horses on a track system. Note that when access to grass is restricted, studies have shown that ponies can learn to eat grass quickly, eating almost half of their daily feed requirement in 3 hours of grazing (Longland et al. 2011).
Regular physical exercise is likely to improve insulin sensitivity and help promote weight loss, and is recommended for EMS horses as long as the feet are stable. The ACVIM consensus statement suggests at least 2-3 sessions of 20-30 minutes of riding or lunging per week, gradually increasing in intensity and duration. Other recommendations for obese horses free of laminitis include riding or lunging 4 to 7 days a week with at least 30 minutes of trot and canter, plus warm up and cool down.
Movement - good or bad?
The ACVIM consensus statement states “Most horses and ponies with EMS can be effectively managed by controlling the horse’s diet, instituting an exercise program, and limiting or eliminating access to pasture.”
Levothyroxine sodium is sometimes given, more commonly in the USA than UK, to induce weight loss.
Metformin is sometimes prescribed for horses that cannot exercise due to laminitis, at the dose of 30 mg/kg bodyweight twice a day. Giving this dose of Metformin before a glucose feed led to reduced glucose and insulin levels compared to controls, but the paper concluded that the potential benefits of giving Metformin to horses on a low NSC diet may be questionable (Rendle et al. 2013).
Whilst various supplements such as magnesium, chromium and cinnamon have been suggested for the management of horses with EMS, currently there is insufficient scientific evidence to support the use of any of these supplements, and where research has been carried out, no or little benefit has been found.
See There are no magic potions!
In theory, yes, EMS is both preventable and reversible. EMS is not a disease, but a collection of factors that increase the risk of endocrinopathic laminitis. Remove these factors (being overweight, having regional fat deposits, having abnormally high insulin levels), and technically the horse no longer has EMS – although some horses with a stronger genetic tendency may always need more careful management than others. The reversal of obesity is likely to have the greatest influence on insulin sensitivity, so make weight loss a priority in overweight horses.
Laminitis, EMS and PPID
Laminitis and the Feet
Diet for horses with laminitis/EMS/PPID
Management Strategies for EMS/Insulin Resistance
Case study: Rosie
Morgan R, Keen J, McGowan C
Equine metabolic syndrome
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Photos: thanks to Kat, Liz and Selina for use of photos.