• Home
    • What we do
    • About TLS
    • TLS Privacy Policy
    • Contact
    • Case Studies
  • Laminitis
    • Emergency Treatment
    • Chronic laminitis
    • Laminitis FAQ
  • EMS/ID
    • Management strategies for EMS/ID
    • EMS/ID FAQ
    • Rosie
  • Diet
    • Diet FAQ
  • PPID
    • PPID FAQ
    • Half Pint
    • Widget
  • Feet
    • Realigning Trim
    • Feet A-Z
    • Chronic laminitis
    • Understanding x-rays
    • Taking hoof photos
    • Feet FAQ & Articles
    • Feet gallery
    • Reading the foot
    • Dorsal rotation/long toes
    • High heels
    • Palmar Angle Calculator
    • Sorrel
    • Monroe
    • Cedar
  • News
  • Articles
  • A-Z
    • A
    • B
    • C
    • D
    • E
    • F
    • G
    • H
    • I
    • J K
    • L
    • M
    • N
    • O
    • P Q
    • R
    • S
    • T
    • U V W X Y Z
  • Case Studies
    • Half Pint
    • Herbie
    • Herbie diary
    • Herbie's TTouch diary
    • Izmir
    • Misty
    • Nutmeg
    • Nutmeg TLS rehab
    • Rosie
    • Sorrel
    • Tex
    • Widget
  • France
    • Articles en francais
  • Research
    • New Research/Research by Date
    • Research papers by subject
    • Research papers by author
    • Research news/comment
    • Research projects >
      • NSC in grass & hay
      • How much do horses eat?
      • Do fructans cause laminitis?
      • Turmeric/Curcumin
      • Insulin response to diet
    • Help with research
  • Help!
    • Join Friends of TLS
    • Donate
    • Appeals
    • Raise funds for TLS
    • In Loving Memory
    • Friends of TLS only
The Laminitis Site

Coleman et al. 2017 Case Control Study of Pasture and Endocrinopathy-Associated Laminitis in Horses

10/29/2017

0 Comments

 
Coleman M, Belknap J, Bramlage L, Eades S, Fraley B, Galantino-Homer H, Hunt R, Geor R, McCue M, McIlwraith W, Moore R, Peroni J, Townsend H, White N, Cummings K, Ivanek-Miojevic R, Cohen N
Case Control Study of Pasture and Endocrinopathy-Associated Laminitis in Horses
Equine Endocrinology Summit 2017 p 25

Significant efforts have been made in the past decade to further our understanding of laminitis in horses; however, much research has been limited to the study of the mechanistic pathways following experimental induction of disease. The conduct of observational studies of naturally-occurring laminitis is necessary for the improvement of our knowledge and understanding of disease predisposition and the design of future investigations into the prevention and control of this debilitating disease. Thus, the objective of this study was to determine risk factors for the development of pasture- and endocrinopathy-associated laminitis (PEAL) in horses evaluated by veterinarians in North America. In this case-control study, incident cases of PEAL evaluated by veterinary practitioners in North America from 2012- 2015 and horses from 2 control populations were included. Participating veterinarians provided historical data from a case of PEAL, a healthy control, and a lameness control. Conditional logistic regression analysis was used to compare data from PEAL-affected horses and each set of controls. A total of 199 horses with acute, incident PEAL, 198 healthy controls, and 153 lameness controls were included in the analysis.

Horses with an obese body condition (BCS ≥ 7), generalized or regional adiposity, a historic diagnosis of an endocrinopathy, and recent glucocorticoid administration were at increased odds of developing PEAL. 

Elucidating the determinants and earlier recognition of obesity, adiposity, and endocrinopathies might be a strategy for reducing the burden of this form of laminitis.

Update August 2018.  See also:
Coleman MC, Belknap JK, Eades SC, Galantino-Homer HL, Hunt RJ, Geor RJ, McCue ME, McIlwraith CW, Moore RM, Peroni JF, Townsend HG, White NA, Cummings KJ, Ivanek-Miojevic R, Cohen ND
Case-control study of risk factors for pasture-and endocrinopathy-associated laminitis in North American horses
J Am Vet Med Assoc. 2018 Aug 15;253(4):470-478. doi: 10.2460/javma.253.4.470

and The Laminitis Laboratory at New Bolton Center post 07 August 2018:
"Take-home bulletpoints from the study for risk factors for Pasture- and Endocrinopathy-Associated Laminitis (PEAL):
- Overweight body condition (BCS >/= 7 out of 9)
- Generalized or Regional adiposity (e.g., "cresty neck")
- Pre-existing endocrinopathy
- Not receiving concentrates in their diet (confounded by BCS since these horses/ponies were probably already recognized by owners/managers to be "easy keepers).
- Had received corticosteroids within 30 days (although presented with the caveat that the study included a low number of cases and controls that had received corticosteroids)
Tons of data collected by participating veterinarians all over the US and Canada made this study possible, which started as the group of authors meeting for a big brainstorming and study design session in Atlanta in 2010, many e-mail discussions, and a lot of hard work by Michelle Coleman of Texas A&M University, the lead author, and her thesis advisor during the study, Noah Cohen."


Let the laminitis data gathering begin! 
Ed Kane, dvm360, Apr 2012
0 Comments

    Archives

    September 2021
    March 2021
    May 2019
    April 2019
    February 2019
    February 2018
    October 2017
    August 2017
    February 2017
    December 2015
    April 2015
    March 2015
    August 2014
    July 2014
    November 2013
    December 2012

    RSS Feed

Laminitis/EMS/PPID? Start here
Need help/support? Join FoTLS
Donate to help laminitic horses
Disclaimer: The information, suggestions and links (hereafter referred to as “information”) contained in this website are provided for information purposes only and should not be relied upon nor replace professional veterinary advice.  Information is non-veterinary, is based as far as possible on current research, does not constitute advice or diagnosis, and should be discussed in full with all relevant vets and hoofcare or other professionals.  No responsibility is taken for the accuracy or suitability of information contained in this website, and no liability accepted for damages of any kind arising from use, reference to or reliance on any information contained in this website.  If you suspect your horse has laminitis or is ill, please consult your vet. 
The Laminitis Site is a charitable company registered in England & Wales No. 8530292, recognized by HMRC as a charity for Gift Aid.  
Please consider making a donation to support the work of The Laminitis Site.
For more information and membership of the TLS support/discussion group, join Friends of The Laminitis Site.
The Laminitis Site's Privacy Policy.