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The Laminitis Site

What causes laminitis?

5/1/2019

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It is now recognised that there are distinct 3 forms of laminitis, each with a different cause:
Endocrinopathic Laminitis (EL) including Pasture Associated Laminitis (PAL)
Sepsis Associated Laminitis (SAL)
Supporting Limb Laminitis (SLL)

Endocrinopathic Laminitis (EL) is thought to make up by far the majority (~90%) of laminitis cases.  This is laminitis caused by Equine Metabolic Sydrome (EMS) with or without PPID, plus corticosteroid-induced laminitis.  Endocrinopathic laminitis includes Pasture Associated Laminitis (PAL), and Pasture and Endocrinopathy-Associated Laminitis may be linked together and called PEAL.  This form of laminitis is commonly seen in overweight and probably underworked horses and ponies, that have unrestricted grazing or a high sugar/starch diet.

Sepsis Associated Laminitis (SAL) occurs secondary to a primary illness, such as colitis, acidosis (from starch overload), infection from retained placenta.  SAL can be thought of as laminitis in an already very sick horse.  SAL is likely to make up less than 10% of laminitis cases, and horses will nearly always have clear indications of infection such as a raised temperature, increased/abnormal white blood cells, and often diarrhoea and/or raised blood lactate.

Supporting limb laminitis (SLL) is rare, and usually seen in horses with a serious lameness such as a fracture or septic joint, and after at least a few days of non-weightbearing on the injured leg - laminitis develops in a supporting leg, often the other front leg if it is a front leg that has the fracture/infection.  SLL can be thought of as laminitis in an already very lame horse.  
Causes of Endocrinopathic/Pasture Associated Laminitis

Coleman M, Belknap J, Bramlage L, Eades S, Fraley B, Galantino-Homer H, Hunt R, Geor R, McCue M, McIlwraith W, Moore R, Peroni J, Townsend H, White N, Cummings K, Ivanek-Miojevic R, Cohen N
Case Control Study of Pasture and Endocrinopathy-Associated Laminitis in Horses
Equine Endocrinology Summit 2017
"Horses with an obese body condition (BCS ≥ 7), generalized or regional adiposity, a historic diagnosis of an endocrinopathy, and recent glucocorticoid administration were at increased odds of developing PEAL."

Research relating to specific causes:

Am J Vet Res. 1995 Jan;56(1):22-6 (PubMed)
Aggregate risk study of exposure to endophyte-infected (Acremonium coenophialum) tall fescue as a risk factor for laminitis in horses
Rohrbach BW, Green EM, Oliver JW, Schneider JF
"Loline and ergot alkaloids found in endophyte-infected (Acremonium coenophialum) tall fescue (EITF) cause vasoconstriction of equine vessels in vitro." 
"Preliminary data support an association between horses exposed to EITF and increased risk of laminitis; however, studies at the individual animal level are indicated to confirm this hypothesis."

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What is the incidence of laminitis?

2/12/2018

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See ​Epidemiology (of laminitis)




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Do wild horses get laminitis?

6/1/2015

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Yes.

Aust Vet J. 2013 Jan-Feb;91(1-2):23-30. doi: 10.1111/avj.12017 (PubMed)
The feral horse foot. Part B: radiographic, gross visual and histopathological parameters of foot health in 100 Australian feral horses.
Hampson BA, de Laat MA, Mills PC, Walsh DM, Pollitt CC.

"Lamellar samples from 15 feet from three populations (of feral horses) were investigated histologically for evidence of laminitis .... Of the three populations surveyed by histopathology, the prevalence of chronic laminitis ranged between 40% and 93%......
CONCLUSIONS:Foot health appeared to be affected by the environment inhabited by the horses. The observed chronic laminitis may be attributable to either nutritional or traumatic causes. Given the overwhelming evidence of suboptimal foot health, it may not be appropriate for the feral horse foot to be the benchmark model for equine foot health."


N Z Vet J. 2012 Sep;60(5):285-9. doi: 10.1080/00480169.2012.682271. Epub 2012 May 24 (PubMed)
Histopathological examination of chronic laminitis in Kaimanawa feral horses of New Zealand.
Hampson BA, de Laat MA, Beausac C, Rovel T, Pollitt CC.

The left fore feet of Kaimanawa feral horses (28 stallions and 28 mares aged 6 - 12 years) were examined.  45% were diagnosed with chronic laminitis.  "The finding suggests that horses are vulnerable to laminitis whether in domestic care or in a feral habitat."

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Do animals other than horses get laminitis?

5/17/2015

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Horses, ponies, donkeys and mules (equids) all get laminitis, but other mammals also get laminitis.  These include cows/cattle, giraffe, chevrotain, takin, giant eland, elephants, llamas.

Vet Q. 2014;34(1):22-8. doi: 10.1080/01652176.2014.905881. Epub 2014 Apr 15.
Severe laminitis in multiple zoo species.
Wiedner E, Holland J, Trupkiewicz J, Uzal F.
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    What causes laminitis?
    Do wild horses get laminitis?
    Do animals other than horses get laminitis?

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Disclaimer: The information, suggestions and links (hereafter referred to as “information”) contained in this website are provided for information purposes only and should not be relied upon nor replace professional veterinary advice.  Information is non-veterinary, is based as far as possible on current research, does not constitute advice or diagnosis, and should be discussed in full with all relevant vets and hoofcare or other professionals.  No responsibility is taken for the accuracy or suitability of information contained in this website, and no liability accepted for damages of any kind arising from use, reference to or reliance on any information contained in this website.  If you suspect your horse has laminitis or is ill, please consult your vet. 
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