Case Control Study of Pasture and Endocrinopathy-Associated Laminitis in Horses
Equine Endocrinology Summit 2017
Significant efforts have been made in the past decade to further our understanding of laminitis in horses; however, much research has been limited to the study of the mechanistic pathways following experimental induction of disease. The conduct of observational studies of naturally-occurring laminitis is necessary for the improvement of our knowledge and understanding of disease predisposition and the design of future investigations into the prevention and control of this debilitating disease. Thus, the objective of this study was to determine risk factors for the development of pasture- and endocrinopathy-associated laminitis (PEAL) in horses evaluated by veterinarians in North America. In this case-control study, incident cases of PEAL evaluated by veterinary practitioners in North America from 2012- 2015 and horses from 2 control populations were included. Participating veterinarians provided historical data from a case of PEAL, a healthy control, and a lameness control. Conditional logistic regression analysis was used to compare data from PEAL-affected horses and each set of controls. A total of 199 horses with acute, incident PEAL, 198 healthy controls, and 153 lameness controls were included in the analysis.
Horses with an obese body condition (BCS ≥ 7), generalized or regional adiposity, a historic diagnosis of an endocrinopathy, and recent glucocorticoid administration were at increased odds of developing PEAL.
Elucidating the determinants and earlier recognition of obesity, adiposity, and endocrinopathies might be a strategy for reducing the burden of this form of laminitis.
Ed Kane, dvm360, Apr 2012