- Liphook now using ACTH > 39 pg/ml as indicating positive for PPID and < 19 pg/ml as indicating negative.
- In 206 paired ACTH samples (5 - 15 minutes apart) from horses suspected of having PPID, 5 horses had both positive and negative results. However, Liphook suggest that the TRH stimulation of ACTH is a better test than testing 2 baseline ACTH samples.
- Post-mortem evidence suggests that using ACTH as the sole test for PPID is likely to underdiagnose the condition - this agrees with findings in the USA that none of the currently available tests for PPID will pick up early histological signs of pituitary dysfunction.
- Liphook is finding the TRH stimulation of ACTH a useful test, and is now using 81 pg/ml (10 minutes after administration?) as the cut-off.
Liphook Equine Hospital Laboratory Newsletter winter 2012/13
Frank Duncombe Laboratory in Normandy (France) is now testing ACTH (EDTA) and insulin (serum), presumably using a similar protocol to Liphook Equine Hospital. Prices we've been told are
ACTH: 37,36€ TTC
Insulin: 19,48 € TTC
Laboratoire Frank Duncombe, 1 Route de Rosel, Saint Contest, 14053 Caen
T: 02 31 47 19 50
What's new in research
Do all IR/EMS horses have laminitis?Clinical signs of PPID may vary with location
Velagliflozin - preventative treatment for endocrinopathic laminitis?
USEF allows pergolide to be taken by competing horses
Risk factors for EMS/Endocrinopathic Laminitis
Seasonal rise in pituitary hormonesPPID - weekly ACTH cutoffs now being used
Do you CARE about laminitis?
Pituitary Pars Intermedia Dysfunction - The Arabian Magazine
EMS & Insulin Dysregulation - The Arabian Magazine
Laminitis and the Feet - The Arabian Magazine
The Arabian Magazine Laminitis article
Paddock Paradise in French
New EEG Recommendations for the diagnosis and treatment of PPID